API PARTICLE SIZE-REDUCTION & CONTROL
ONE TECHNOLOGY – MULTIPLE WET MILLING SOLUTIONS IN PHARMA
Precise API particle size reduction is a critical step in pharmaceutical manufacturing. From improving dissolution rate and bioavailability to ensuring formulation stability, particle size directly impacts drug performance.
ProXES wet milling technologies enable the reduction of API crystal size to micron and submicron levels within a narrow distribution range — efficiently, reproducibly and scalable.
WHY API PARTICLE SIZE MATTERS
- Improved bioavailability and faster dissolution rates
- Controlled and narrow particle size distribution
- Increased process efficiency and throughput
- Reduced milling time and minimized material loss
- Reliable scalability from lab to production
Good to know: A well-established particle size reduction process does not only improve product performance — it ensures reproducibility, compliance and cost efficiency.
WHICH TECHNOLOGY FITS YOUR STRATEGY?
Your technology choice depends on target particle size, viscosity, formulation requirements and scalability goals:
MZ – COLLIOD MILL
Best suited for fine suspensions and emulsions
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High rotor speed and narrow gap setting
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High shear and impact forces
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Exchangeable colloid milling sets
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Flexible adaptation to pharma-specific requirements
MS – COBALL® MILL
Versatile and ideal for demanding pharmaceutical applications.
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Fine milling of suspensions and high-viscous products
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Suitable for API size reduction down to submicron range
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Narrow and controlled particle size distribution
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Cost-effective and efficient operation
DIL – INLINE HOMOGENIZER
High-performance inline solution with excellent scale-up capabilities.
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Rotor/stator design across all machine sizes
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Identical circumferential rotor speed for reliable scale-up
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Suitable for emulsions and suspensions
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Narrow distribution range with robust processing
Ready to sharpen your skills?
Discover our upcoming seminars and build practical know-how with expert-led, hands-on sessions.
FROM IDEA TO MARKET-READY PRODUCT
At the ProXES Process Technology & Training Center, you can:
- Test new recipes
- Trial machines & technologies
- Scale up production efficiently
The challenge: adapting recipes without compromising taste, texture, or shelf life. ProXES solutions make it possible.
Talk to an expert!
Please don't hesitate to reach out to us. If you have any additional questions, we are here to assist you and provide the information you need.
We look forward to meeting you and making your vision a reality.
